Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.31 |
| ▸ | STK17B | O94768 | 1/20 | 0.31 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.30 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.30 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2874208 | 0.88 | KDM4E (0.38) | KDM4EHTTATMUSP30NR1I2 | |
| SCHEMBL2877206 | 0.88 | KDM4E (0.38) | KDM4EHTTATMUSP30NR1I2 | |
| SCHEMBL2874240 | 0.88 | KDM4E (0.38) | KDM4EHTTATMUSP30NR1I2 | |
| SCHEMBL2874935 | 0.88 | NR1I2 (0.39) | HDAC1HDAC6MCHR1KDM4ECHEK1 | |
| SCHEMBL2879111 | 0.88 | IKBKB (0.37) | KDM4EHTTATM | |
| SCHEMBL2881302 | 0.88 | HSD17B1 (0.34) | KDM4ECHEK1MAP3K8HTTATM | |
| SCHEMBL2874941 | 0.87 | NPC1 (0.36) | HDAC6KDM4ECHEK1MAP3K8HTT | |
| SCHEMBL2878697 | 0.87 | HDAC6 (0.31) | HDAC6CHEK1STK17B | |
| SCHEMBL2876896 | 0.84 | NR1I2 (0.31) | NR1I2 | |
| SCHEMBL2879449 | 0.84 | KDM4E (0.36) | KDM4EHTTATMUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569929-B9 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | VIROCHEM PHARMA INC (CA) | 2011-09-14 | — | — | EP | claimed |
| EP-1569929-B1 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | VIROCHEM PHARMA INC (CA) | 2010-05-05 | — | — | EP | claimed |