Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.50 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27872125 | 0.81 | KDM4E (0.53) | ALDH1A1SMN1; SMN2POLBCYP3A4BLM | |
| SCHEMBL5939825 | 0.80 | PRSS1 (0.55) | ALDH1A1SMN1; SMN2POLBEPHX2TP53 | |
| SCHEMBL12368426 | 0.79 | ALDH1A1 (0.65) | ALDH1A1NFKB1KCNH2SMN1; SMN2POLB | |
| SCHEMBL5508324 | 0.76 | ALDH1A1 (0.70) | ALDH1A1NFKB1KCNH2SMN1; SMN2POLB | |
| SCHEMBL2924725 | 0.76 | CACNA1B (0.65) | ALDH1A1NFKB1KCNH2SMN1; SMN2POLB | |
| SCHEMBL11196763 | 0.75 | ALDH1A1 (0.64) | ALDH1A1NFKB1KCNH2SMN1; SMN2POLB | |
| SCHEMBL630156 | 0.75 | ALDH1A1 (0.56) | ALDH1A1NFKB1KCNH2SMN1; SMN2POLB | |
| SCHEMBL10755434 | 0.75 | SMN1; SMN2 (0.63) | ALDH1A1NFKB1KCNH2SMN1; SMN2POLB | |
| SCHEMBL13922754 | 0.74 | ALDH1A1 (0.59) | ALDH1A1NFKB1KCNH2SMN1; SMN2POLB | |
| SCHEMBL7478908 | 0.74 | ALDH1A1 (0.59) | ALDH1A1NFKB1KCNH2SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102449165-B | Genetic markers for risk management of atrial fibrillation and stroke | DECODE GENETICS EHF | 2014-07-09 | — | — | CN | disclosed |
| CN-102449165-A | Genetic markers for risk management of atrial fibrillation and stroke | DECODE GENETICS EHF | 2012-05-09 | — | — | CN | disclosed |