Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | CYP2A13 | Q16696 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3766430 | 0.89 | CYP2A13 (0.50) | CTSBCYP2A13ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3774742 | 0.84 | CTSB (0.53) | CTSBCYP2A13ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL28814466 | 0.81 | CTSB (0.50) | CTSBCYP2A13ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL9060482 | 0.81 | CYP2A13 (0.61) | CTSBCYP2A13ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL28795439 | 0.80 | CTSB (0.46) | CTSBCYP2A13ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL27873042 | 0.77 | CTSB (0.46) | CTSBCYP2A13ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2130743 | 0.77 | CTSB (0.46) | CTSBCYP2A13ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL9008678 | 0.75 | ACHE (0.65) | CTSBCYP2A13ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2141932 | 0.74 | HCRTR1 (0.52) | CTSBCYP2A13ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6526231 | 0.74 | POLB (0.47) | CTSBALDH1A1SMN1; SMN2MAPTKCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102482221-B | bicyclic and tricyclic compounds as KATII inhibitors | PFIZER INC. (US) | 2014-10-22 | — | — | CN | disclosed |
| CN-102482221-A | Bicyclic and tricyclic compounds as KATII inhibitors | PFIZER | 2012-05-30 | — | — | CN | disclosed |