Quinoline

Quinoline

SCHEMBL28798085

c1ccc2[nH]ccc2c1.c1ccc2ncccc2c1.c1cocn1

nearest known ligand 0.46

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.46
TRPA1 O75762 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
ITGB2 P05107 1/20 0.46
ICAM1 P05362 1/20 0.46
ITGAL P20701 1/20 0.46
CA4 P22748 1/20 0.46
CA6 P23280 1/20 0.46
AHR P35869 1/20 0.46
ADK P55263 1/20 0.46
AXL P30530 1/20 0.38
NUDT1 P36639 1/20 0.38
PSMD14 O00487 1/20 0.35
NR4A2 P43354 1/20 0.33
NPC1 O15118 4/20 0.32
RAB9A P51151 4/20 0.32
POLB P06746 1/20 0.32
MAPT P10636 2/20 0.32
GAA P10253 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isoquinoline SCHEMBL27793706 0.92 ALDH1A1 (0.39) ALDH1A1TRPA1CA1CA2ITGB2
Indole SCHEMBL7260953 0.89 AHR (0.59) ALDH1A1TRPA1CA1CA2ITGB2
Quinoline SCHEMBL28862645 0.86 ALDH1A1 (0.52) ALDH1A1TRPA1CA1CA2ITGB2
Quinoline SCHEMBL28292512 0.85 ALDH1A1 (0.63) ALDH1A1TRPA1CA1CA2ITGB2
Quinoline SCHEMBL28816675 0.85 ALDH1A1 (0.63) ALDH1A1TRPA1CA1CA2ITGB2
Quinoline SCHEMBL843861 0.85 ALDH1A1 (0.63) ALDH1A1TRPA1CA1CA2ITGB2
Quinoline SCHEMBL28073739 0.85 ALDH1A1 (0.63) ALDH1A1TRPA1CA1CA2ITGB2
Quinoline SCHEMBL27296262 0.85 ALDH1A1 (0.63) ALDH1A1NR4A2NPC1RAB9APOLB
Quinoline SCHEMBL28231339 0.84 ALDH1A1 (0.61) ALDH1A1NR4A2NPC1RAB9APOLB
Quinoline SCHEMBL27739225 0.84 ALDH1A1 (0.61) ALDH1A1TRPA1CA1CA2ITGB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102712661-A Method for producing perfluoroalkyl cyanoborates or perfluoroalkyl cyanofluoroborates MERCK PATENT GMBH 2012-10-03 CN claimed
CN-102712661-B Prepare the method for perfluoroalkyl cyano group borate or perfluoroalkyl cyano group fluoroborate MERCK PATENT GMBH (DE) 2016-02-17 CN disclosed
CN-102712661-A Method for producing perfluoroalkyl cyanoborates or perfluoroalkyl cyanofluoroborates MERCK PATENT GMBH 2012-10-03 CN disclosed