SCHEMBL28800490

SCHEMBL28800490

O=[C]C1CCCN(CCc2ccc3c(c2)OCO3)C1

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.47
MCHR1 Q99705 5/20 0.46
KDM4E B2RXH2 3/20 0.46
DPP7 Q9UHL4 1/20 0.45
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
ADRA1D P25100 1/20 0.44
ADRA1A P35348 1/20 0.44
ADRA1B P35368 1/20 0.44
MAPK1 P28482 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
MMP1 P03956 1/20 0.43
MMP7 P09237 1/20 0.43
MMP8 P22894 1/20 0.43
MMP12 P39900 1/20 0.43
MMP13 P45452 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4812050 0.84 MCHR1 (0.50) ALDH1A1MCHR1KDM4EDPP7MEN1
SCHEMBL4391727 0.81 ALDH1A1 (0.49) ALDH1A1MCHR1KDM4EDPP7MEN1
SCHEMBL6801075 0.81 DPP7 (0.50) ALDH1A1MCHR1KDM4EDPP7MEN1
SCHEMBL6270367 0.80 ALDH1A1 (0.47) ALDH1A1MCHR1KDM4EDPP7MEN1
SCHEMBL11698547 0.79 DPP7 (0.67) ALDH1A1DPP7ADRA1DADRA1AADRA1B
SCHEMBL11261146 0.78 DPP7 (0.65) ALDH1A1DPP7KMT2AADRA1DADRA1A
SCHEMBL28800482 0.77 ALDH1A1 (0.53) ALDH1A1MCHR1KDM4EMEN1KMT2A
SCHEMBL5918375 0.77 ADRA1D (0.46) KDM4EDPP7MEN1KMT2AADRA1D
SCHEMBL5918372 0.77 ADRA1D (0.46) KDM4EDPP7MEN1KMT2AADRA1D
SCHEMBL9670197 0.77 KMT2A (0.50) MCHR1KMT2AADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101928280-B Pepperphentonamine derivative containing naphthalene rings GUANGZHOU ZHONGWEI BIOTECHNOLOGY CO LTD 2012-09-12 CN disclosed