Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5151141 | 0.77 | ALDH1A1 (0.51) | MAP4K4DAPK3PRKD3ABL1NTRK1 | |
| SCHEMBL29217099 | 0.74 | DAPK3 (0.43) | MAP4K4DAPK3PRKD3ABL1NTRK1 | |
| SCHEMBL29217102 | 0.74 | DAPK3 (0.43) | MAP4K4DAPK3PRKD3ABL1NTRK1 | |
| SCHEMBL7089546 | 0.72 | KMT2A (0.48) | ALDH1A1CYP2A6HSD17B10LMNASMN1; SMN2 | |
| SCHEMBL8219401 | 0.70 | ALDH1A1 (0.49) | MAP4K4DAPK3PRKD3ABL1NTRK1 | |
| SCHEMBL3792808 | 0.69 | ALDH1A1 (0.41) | MAP4K4DAPK3PRKD3ABL1NTRK1 | |
| SCHEMBL28687350 | 0.69 | BTK (0.44) | MAP4K4DAPK3PRKD3ABL1NTRK1 | |
| SCHEMBL6271882 | 0.69 | ALDH1A1 (0.54) | MAP4K4DAPK3PRKD3ABL1NTRK1 | |
| SCHEMBL15391338 | 0.69 | PDPK1 (0.47) | MAP4K4DAPK3PRKD3ABL1NTRK1 | |
| SCHEMBL8649337 | 0.68 | CYP2A6 (0.60) | ALDH1A1CYP2A6HSD17B10HPGDCYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102970868-A | Treatment of cancers having K-RAS mutations | CURIS INC | 2013-03-13 | — | — | CN | disclosed |