SCHEMBL28801722

SCHEMBL28801722

CC1CC(C=O)N(c2cccc(Cl)c2)N1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 3/20 0.44
HTR3E A5X5Y0 2/20 0.39
HTR3B O95264 2/20 0.39
HTR3A P46098 2/20 0.39
HTR3D Q70Z44 2/20 0.39
HTR3C Q8WXA8 2/20 0.39
TP53 P04637 1/20 0.39
CYP1A2 P05177 1/20 0.39
ADRB1 P08588 1/20 0.39
CYP3A4 P08684 1/20 0.39
HTR1A P08908 1/20 0.39
CYP2D6 P10635 1/20 0.39
THRB P10828 1/20 0.39
CYP2C9 P11712 1/20 0.39
HTR2A P28223 1/20 0.39
HTR2C P28335 1/20 0.39
SLC6A4 P31645 1/20 0.39
CYP2C19 P33261 1/20 0.39
HTR7 P34969 1/20 0.39
HTR2B P41595 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27689041 0.83 ALOX5 (0.37) ALOX5
SCHEMBL28500811 0.68 HTR2A (0.52) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL1133351 0.66 ALOX5 (0.52) ALOX5HTR3EHTR3BHTR3AHTR3D
SCHEMBL27492442 0.66 HTR2C (0.53) ALOX5HTR3EHTR3BHTR3AHTR3D
SCHEMBL28523211 0.66 KMT2A (0.47) HTR3EHTR3BHTR3AHTR3DHTR3C
Hydrochloric Acid SCHEMBL28764973 0.65 HTR2C (0.51) ALOX5HTR3EHTR3BHTR3AHTR3D
SCHEMBL27743313 0.65 ALOX5 (0.48) ALOX5HTR3EHTR3BHTR3AHTR3D
SCHEMBL27318116 0.64 HTR2A (0.43) ALOX5HTR3EHTR3BHTR3AHTR3D
SCHEMBL28430900 0.64 PRKCZ (0.42) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL30208169 0.64 MGLL (0.43) HTR3EHTR3BHTR3AHTR3DHTR3C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102797043-B Medicinal molecular fragment library and construction process thereof Tianli (Tianjin) Technology Co., Ltd. (CN) 2015-11-25 CN claimed
CN-102797043-A Medicinal molecular fragment library and construction method thereof CBB NETWORK CO LTD 2012-11-28 CN claimed
CN-102797043-B Medicinal molecular fragment library and construction process thereof Tianli (Tianjin) Technology Co., Ltd. (CN) 2015-11-25 CN disclosed
CN-102797043-A Medicinal molecular fragment library and construction method thereof CBB NETWORK CO LTD 2012-11-28 CN disclosed