SCHEMBL28801723

SCHEMBL28801723

COc1cc(-c2cccs2)on1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 9/20 0.51
NPC1 O15118 7/20 0.51
SMN1; SMN2 Q16637 6/20 0.51
LMNA P02545 3/20 0.50
HPGD P15428 2/20 0.50
KMT2A Q03164 6/20 0.49
ALDH1A1 P00352 5/20 0.49
MEN1 O00255 5/20 0.49
KDM4E B2RXH2 5/20 0.49
MAPT P10636 5/20 0.49
HSD17B10 Q99714 3/20 0.49
TP53 P04637 2/20 0.49
NPSR1 Q6W5P4 1/20 0.49
ESR1 P03372 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
MAPK1 P28482 2/20 0.46
NFKB1 P19838 1/20 0.46
NFKB2 Q00653 1/20 0.46
RELA Q04206 1/20 0.46
PKM P14618 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4140152 0.77 RAB9A (0.51) RAB9ANPC1SMN1; SMN2LMNAHPGD
SCHEMBL5617566 0.76 RAB9A (0.45) RAB9ANPC1SMN1; SMN2LMNAHPGD
Acetonitrile SCHEMBL7372452 0.76 KDM4E (0.43) RAB9ANPC1SMN1; SMN2LMNAHPGD
Hydrochloric Acid SCHEMBL8376217 0.75 RAB9A (0.44) RAB9ANPC1SMN1; SMN2LMNAHPGD
SCHEMBL20507129 0.74 KMT2A (0.71) RAB9ANPC1SMN1; SMN2LMNAHPGD
Hydrochloric Acid SCHEMBL7273103 0.74 RAB9A (0.46) RAB9ANPC1SMN1; SMN2LMNAHPGD
SCHEMBL8377420 0.73 RAB9A (0.51) RAB9ANPC1SMN1; SMN2LMNAHPGD
SCHEMBL4140149 0.73 RAB9A (0.48) RAB9ANPC1SMN1; SMN2LMNAHPGD
SCHEMBL10342451 0.73 RAB9A (0.58) RAB9ANPC1SMN1; SMN2HPGDKMT2A
SCHEMBL12051092 0.72 THRB (0.51) RAB9ANPC1SMN1; SMN2LMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102797043-B Medicinal molecular fragment library and construction process thereof Tianli (Tianjin) Technology Co., Ltd. (CN) 2015-11-25 CN claimed
CN-102797043-A Medicinal molecular fragment library and construction method thereof CBB NETWORK CO LTD 2012-11-28 CN claimed
CN-102797043-B Medicinal molecular fragment library and construction process thereof Tianli (Tianjin) Technology Co., Ltd. (CN) 2015-11-25 CN disclosed
CN-102797043-A Medicinal molecular fragment library and construction method thereof CBB NETWORK CO LTD 2012-11-28 CN disclosed