Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glutamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GRM8 | O00222 | 1/20 | 0.31 |
| ▸ | GRM6 | O15303 | 1/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GSR | P00390 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.31 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.31 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.31 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamine SCHEMBL6255119 | 0.96 | ALOX15 (0.38) | ALOX15BLMPMP22KMT2ASLC1A3 | |
| Glutamine SCHEMBL1304984 | 0.96 | KMT2A (0.45) | ALOX15BLMPMP22KMT2AGRM8 | |
| Glutamine SCHEMBL27639978 | 0.96 | KMT2A (0.45) | ALOX15BLMPMP22KMT2AGRM8 | |
| Asparagine SCHEMBL28801799 | 0.93 | NOS2 (0.33) | ALOX15KMT2ACYP1A2GRIK1GRIA1 | |
| Asparagine SCHEMBL3864508 | 0.93 | NOS2 (0.33) | ALOX15KMT2ACYP1A2GRIK1GRIA1 | |
| Glutamine SCHEMBL28152470 | 0.92 | ALOX15 (0.35) | ALOX15BLMPMP22KMT2A | |
| Glutamine SCHEMBL10428556 | 0.91 | ALOX15 (0.41) | ALOX15BLMPMP22KMT2AGRM8 | |
| Glutamine SCHEMBL28719330 | 0.91 | ALOX15 (0.41) | ALOX15BLMPMP22KMT2AGRM8 | |
| Glutamine SCHEMBL27823468 | 0.91 | ALOX15 (0.41) | ALOX15BLMPMP22KMT2AGRM8 | |
| Glutamine SCHEMBL10428553 | 0.91 | ALOX15 (0.41) | ALOX15BLMPMP22KMT2AGRM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114853848-B | Polypeptide compound and application thereof in preparation of medicines for treating liver fibrosis diseases | 陕西慧康生物科技有限责任公司 | 2023-10-24 | — | — | CN | disclosed |
| CN-114853848-A | Polypeptide compound and application thereof in preparing medicament for treating hepatic fibrosis diseases | 陕西慧康生物科技有限责任公司 | 2022-08-05 | — | — | CN | disclosed |