Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Asparagine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.33 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.33 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
| ▸ | PRCP | P42785 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Asparagine SCHEMBL3864508 | 1.00 | NOS2 (0.33) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Asparagine SCHEMBL3442870 | 0.96 | SLC7A5 (0.35) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Asparagine SCHEMBL28801819 | 0.95 | CD274 (0.33) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Leucine SCHEMBL28801806 | 0.95 | SLC7A5 (0.41) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Glutamine SCHEMBL28801797 | 0.93 | ALOX15 (0.41) | GRIK1GRIK2GRIA2GRIA4GRIK3 | |
| Isoleucine SCHEMBL28801805 | 0.93 | REN (0.33) | NOS2NOS3NOS1DPP7 | |
| Leucine SCHEMBL29042983 | 0.91 | SLC7A5 (0.38) | SLC7A5 | |
| Lysine SCHEMBL28801803 | 0.90 | GSR (0.41) | NOS2NOS3NOS1DPP7CYP1A2 | |
| Asparagine SCHEMBL2440846 | 0.90 | NOS2 (0.37) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Asparagine SCHEMBL4354914 | 0.90 | NOS2 (0.37) | NOS2NOS3NOS1GRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114853848-B | Polypeptide compound and application thereof in preparation of medicines for treating liver fibrosis diseases | 陕西慧康生物科技有限责任公司 | 2023-10-24 | — | — | CN | disclosed |
| CN-114853848-A | Polypeptide compound and application thereof in preparing medicament for treating hepatic fibrosis diseases | 陕西慧康生物科技有限责任公司 | 2022-08-05 | — | — | CN | disclosed |