SCHEMBL1534089

SCHEMBL1534089

Cc1ccccc1NC(=O)OC(C)(C)C

nearest known ligand 0.74

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.58
RAB9A P51151 3/20 0.58
HPGD P15428 3/20 0.56
ALDH1A1 P00352 2/20 0.56
PDK1 Q15118 1/20 0.53
PDK2 Q15119 1/20 0.53
PDK3 Q15120 1/20 0.53
PDK4 Q16654 1/20 0.53
POLB P06746 3/20 0.51
BRD9 Q9H8M2 1/20 0.49
MAPT P10636 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
LMNA P02545 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
ALOX12 P18054 1/20 0.49
RXFP1 Q9HBX9 1/20 0.48
KMT2A Q03164 1/20 0.48
EPHX1 P07099 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
O-Tolylamine SCHEMBL19586028 0.91 NPC1 (0.49) NPC1RAB9AHPGDALDH1A1PDK1
SCHEMBL2880191 0.89 LMNA (0.54) NPC1RAB9AHPGDALDH1A1POLB
SCHEMBL4414634 0.87 LMNA (0.48) NPC1RAB9AHPGDALDH1A1PDK1
SCHEMBL2880194 0.86 BRD9 (0.52) NPC1RAB9AHPGDALDH1A1POLB
SCHEMBL8348015 0.84 PDK1 (0.52) NPC1RAB9AHPGDALDH1A1PDK1
SCHEMBL1006923 0.83 LCK (0.45) NPC1RAB9APOLBBRD9LMNA
SCHEMBL29493510 0.83 LCK (0.45) NPC1RAB9APOLBBRD9LMNA
SCHEMBL28856066 0.83 RXFP1 (0.47) NPC1RAB9APDK1PDK2PDK3
SCHEMBL21681358 0.83 LCK (0.46) ALDH1A1PDK1PDK2PDK3PDK4
SCHEMBL9685813 0.83 LCK (0.45) NPC1RAB9AHPGDALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250214974-A1 INHIBITING MONOACYLGLYCEROL LIPASE (MAGL) PSY THERAPEUTICS, INC. (US) 2025-07-03 US disclosed
US-20250170101-A1 MONOACYLGLYCEROL LIPASE INHIBITORS AND USE THEREOF FOR THE TREATMENT AND MANAGEMENT OF PAIN AND RELATED CONDITIONS PSY THERAPEUTICS, INC. (US) 2025-05-29 US disclosed
US-20250170100-A1 MONOACYLGLYCEROL LIPASE INHIBITORS AND USE THEREOF FOR THE TREATMENT OF ANXIETY AND RELATED CONDITIONS PSY THERAPEUTICS, INC. (US) 2025-05-29 US disclosed
US-12286421-B2 Inhibiting monoacylglycerol lipase (MAGL) PSY THERAPEUTICS, INC. (US) 2025-04-29 US disclosed
US-20250084065-A1 INHIBITING MONOACYLGLYCEROL LIPASE (MAGL) PSY THERAPEUTICS, INC. (US) 2025-03-13 US disclosed
WO-2025010394-A2 MONOACYLGLYCEROL LIPASE INHIBITORS AND USE THEREOF FOR THE TREATMENT AND MANAGEMENT OF INFLAMMATORY CONDITIONS PSY THERAPEUTICS, INC. (US) 2025-01-09 WO disclosed
WO-2025010392-A2 MONOACYLGLYCEROL LIPASE INHIBITORS AND USE THEREOF FOR THE TREATMENT OF NEUROLOGICAL DISORDERS PSY THERAPEUTICS, INC. (US) 2025-01-09 WO disclosed
EP-4457213-A1 INHIBITING MONOACYLGLYCEROL LIPASE (MAGL) Psy Therapeutics, Inc. (US) 2024-11-06 EP disclosed
US-20240308985-A1 INHIBITING MONOACYLGLYCEROL LIPASE (MAGL) PSY THERAPEUTICS, INC. (US) 2024-09-19 US disclosed
CN-118574807-A Inhibition of monoacylglycerol lipase (MAGL) PSY治疗公司 2024-08-30 CN disclosed
EP-1020439-A1 CETP ACTIVITY INHIBITORS JAPAN TOBACCO INC. (JP) 2000-07-19 EP disclosed
EP-0914125-A4 HIV PROTEASE INHIBITORS USEFUL FOR THE TREATMENT OF AIDS MERCK & CO INC (US) 2000-04-05 EP disclosed
US-5968924-A HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS MERCK & CO., INC. (US) 1999-10-19 US disclosed
EP-0914125-A1 HIV PROTEASE INHIBITORS USEFUL FOR THE TREATMENT OF AIDS Merck & Co., Inc. (US) 1999-05-12 EP disclosed
US-5846978-A HIV protease inhibitors useful for the treatment of AIDS MERCK & CO., INC. (US) 1998-12-08 US disclosed
WO-1997040833-A1 HIV PROTEASE INHIBITORS USEFUL FOR THE TREATMENT OF AIDS MERCK & CO., INC. (US) 1997-11-06 WO disclosed
EP-0082523-B1 INTERMEDIATES FOR THE PREPARATION OF 4-PHENYL-1,3-BENZODIAZEPINS AND METHODS FOR PREPARING THE INTERMEDIATES HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1986-04-02 EP disclosed
US-4461728-A Preparation of 4-phenyl-1,3-benzodiazepins HOECHST ROUSSEL PHARMACEUTICALS INC. (US) 1984-07-24 US disclosed
EP-0082523-A2 Intermediates for the preparation of 4-phenyl-1,3-benzodiazepins and methods for preparing the intermediates HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1983-06-29 EP disclosed
US-4374067-A Intermediates for the preparation of 4-phenyl-1,3-benzodiazepins and methods for preparing the intermediates HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1983-02-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250214974-A1 INHIBITING MONOACYLGLYCEROL LIPASE (MAGL) MGLL, PNLIP, LIPC NPC1 334/4885RAB9A 1093/4885HPGD 2668/4885
US-20250084065-A1 INHIBITING MONOACYLGLYCEROL LIPASE (MAGL) MGLL, PNLIP, LPL NPC1 300/4885RAB9A 2094/4885HPGD 835/4885
US-12286421-B2 Inhibiting monoacylglycerol lipase (MAGL) MGLL, PNLIP, LIPC NPC1 334/4885RAB9A 1093/4885HPGD 2668/4885
US-20250170101-A1 MONOACYLGLYCEROL LIPASE INHIBITORS AND USE THEREOF FOR THE TREATMENT AND MANAGEMENT OF PAIN AND RELATED CONDITIONS MGLL, PNLIP, LIPA NPC1 982/4885RAB9A 1440/4885HPGD 670/4885
US-20250170100-A1 MONOACYLGLYCEROL LIPASE INHIBITORS AND USE THEREOF FOR THE TREATMENT OF ANXIETY AND RELATED CONDITIONS MGLL, PNLIP, LIPA NPC1 563/4885RAB9A 1248/4885HPGD 1662/4885
US-20240308985-A1 INHIBITING MONOACYLGLYCEROL LIPASE (MAGL) MGLL, PNLIP, LIPC NPC1 334/4885RAB9A 1093/4885HPGD 2668/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.