Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | METAP1 | P53582 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2880191 | 0.93 | LMNA (0.54) | BRD9LMNAPOLBRXFP1BRD4 | |
| SCHEMBL1534089 | 0.86 | NPC1 (0.58) | BRD9LMNAPOLBRXFP1NPC1 | |
| SCHEMBL736662 | 0.86 | POLB (0.49) | BRD9LMNAPOLBRXFP1BRD4 | |
| SCHEMBL2829176 | 0.85 | POLB (0.56) | POLBRXFP1NPC1RAB9AMEN1 | |
| SCHEMBL15711990 | 0.84 | LMNA (0.48) | BRD9LMNAPOLBRXFP1BRD4 | |
| SCHEMBL22735089 | 0.83 | LMNA (0.47) | BRD9LMNAPOLBRXFP1BRD4 | |
| SCHEMBL29991524 | 0.83 | POLB (0.50) | LMNAPOLBRXFP1MEN1GAA | |
| SCHEMBL222446 | 0.83 | RXFP1 (0.55) | BRD9LMNAPOLBRXFP1NPC1 | |
| SCHEMBL29702265 | 0.83 | RXFP1 (0.55) | BRD9LMNAPOLBRXFP1NPC1 | |
| SCHEMBL13980716 | 0.83 | POLB (0.50) | LMNAPOLBRXFP1MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043866-A2 | HISTONE LYSINE DEMETHYLASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2010-04-22 | — | — | WO | disclosed |