Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAK | O14976 | 3/20 | 0.41 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.41 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.41 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.41 |
| ▸ | TXK | P42681 | 1/20 | 0.41 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.40 |
| ▸ | STK16 | O75716 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4421437 | 0.83 | RIPK2 (0.53) | RIPK2KDRMAPK14SLC22A12GAK | |
| Ethoxycarbonyl Group SCHEMBL27699207 | 0.78 | ERN1 (0.42) | RIPK2ALDH1A1MAPTPOLBCYP1A2 | |
| Ethoxycarbonyl Group SCHEMBL27796056 | 0.74 | HTR1A (0.43) | SLC22A12ALDH1A1CHEK1PIM1RPS6KA3 | |
| Ethoxycarbonyl Group SCHEMBL27775096 | 0.74 | TLR8 (0.36) | GAAALDH1A1L3MBTL1MAPTPOLB | |
| Ethoxycarbonyl Group SCHEMBL28282915 | 0.74 | L3MBTL1 (0.46) | GAAALDH1A1L3MBTL1MAPTCYP1A2 | |
| Ethoxycarbonyl Group SCHEMBL27877278 | 0.72 | MAOB (0.40) | GAAALDH1A1L3MBTL1GAKMAPT | |
| SCHEMBL5407537 | 0.71 | SLC22A12 (0.46) | RIPK2KDRMAPK14SLC22A12GAK | |
| SCHEMBL28235623 | 0.71 | RIPK2 (0.42) | RIPK2KDRMAPK14SLC22A12GAK | |
| Ethoxycarbonyl Group SCHEMBL28284394 | 0.71 | L3MBTL1 (0.52) | KDRGAAALDH1A1L3MBTL1CLK2 | |
| SCHEMBL2345433 | 0.71 | ADRB2 (0.51) | RIPK2KDRMAPK14SLC22A12GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103097375-B | Cyclohexyl-azetidine the antagonist of CCR2 | JANSSEN PHARMACEUTICA N.V. (BE) | 2015-08-12 | — | — | CN | disclosed |
| CN-103097375-A | Cyclohexyl-azetidinyl antagonists of CCR2 | JANSSEN PHARMACEUTICA NV | 2013-05-08 | — | — | CN | disclosed |