Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 11/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5262791 | 0.81 | KEAP1 (0.50) | KEAP1NFE2L2KIF11POLBCHRM3 | |
| SCHEMBL6453670 | 0.77 | POLB (0.44) | KEAP1NFE2L2KIF11POLBCHRM3 | |
| SCHEMBL29116795 | 0.74 | KEAP1 (0.56) | KEAP1NFE2L2KIF11POLBCHRM3 | |
| SCHEMBL27624848 | 0.73 | KEAP1 (0.42) | KEAP1NFE2L2KIF11POLBCHRM3 | |
| SCHEMBL4283827 | 0.73 | CHRM3 (0.53) | KEAP1NFE2L2KIF11POLBCHRM3 | |
| SCHEMBL2763726 | 0.73 | KEAP1 (0.56) | KEAP1NFE2L2KIF11POLBCHRM3 | |
| SCHEMBL4475515 | 0.72 | KEAP1 (0.54) | KEAP1NFE2L2KIF11CHRM3CHRM2 | |
| SCHEMBL360473 | 0.71 | KEAP1 (0.72) | KEAP1NFE2L2POLBCHRM3CHRM2 | |
| SCHEMBL9516976 | 0.71 | KEAP1 (0.53) | KEAP1NFE2L2KIF11POLBCHRM3 | |
| SCHEMBL4618170 | 0.71 | KEAP1 (0.72) | KEAP1NFE2L2POLBCHRM3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103097340-A | Therapeutically active compositions and methods of use thereof | AGIOS PHARMACEUTICALS INC | 2013-05-08 | — | — | CN | disclosed |