⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2896396 | 1.00 | — | — | |
| SCHEMBL14692211 | 1.00 | — | — | |
| SCHEMBL26468788 | 0.87 | — | — | |
| SCHEMBL1503804 | 0.84 | CYP1A2 (0.31) | — | |
| SCHEMBL158240 | 0.84 | CYP1A2 (0.31) | — | |
| SCHEMBL26468519 | 0.81 | CHRNB2 (0.34) | — | |
| SCHEMBL25403368 | 0.81 | — | — | |
| SCHEMBL25403790 | 0.81 | — | — | |
| SCHEMBL25334261 | 0.79 | PTPN2 (0.31) | — | |
| SCHEMBL25335341 | 0.79 | PTPN2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE49481-E1 | Compounds for the treatment and prophylaxis of respiratory syncytial virus disease | HOFFMANN-LA ROCHE INC. (US) | 2023-04-04 | — | — | US | disclosed |
| US-20230093692-A1 | C10-Alkylene Substituted 13-Membered Macrolides and Uses Thereof | ZIKANI THERAPEUTICS, INC. | 2023-03-23 | — | — | US | disclosed |
| EP-3883647-A1 | C10-ALKYLENE SUBSTITUTED 13-MEMBERED MACROLIDES AND USES THEREOF | Zikani Therapeutics, Inc. (US) | 2021-09-29 | — | — | EP | disclosed |
| EP-2742039-B1 | COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS DISEASE | HOFFMANN LA ROCHE (CH) | 2015-09-16 | — | — | EP | disclosed |
| US-8871756-B2 | Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease | HOFFMANN-LA ROCHE INC. (US) | 2014-10-28 | — | — | US | disclosed |
| US-20130196974-A1 | COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS DISEASE | HOFFMANN-LA ROCHE INC. | 2013-08-01 | — | — | US | disclosed |
| US-7855294-B2 | Cycloalkanopyridine derivative | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-12-21 | — | — | US | disclosed |
| US-20070191419-A1 | Cycloalkanopyridine derivative | MSD K.K. (JP) | 2007-08-16 | — | — | US | disclosed |
| EP-1726590-A1 | CYCLOALKANOPYRIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-11-29 | — | — | EP | disclosed |
| EP-1446402-B1 | 2-AMINO-4-HETEROARYLETHYL THIAZOLINE DERIVATIVES AND THEIR USE AN INHIBITORS OF INDUCIBLE NO-SYNTHASE | AVENTIS PHARMA SA (FR) | 2005-11-02 | — | — | EP | disclosed |
| EP-1446402-A1 | 2-AMINO-4-HETEROARYLETHYL THIAZOLINE DERIVATIVES AND THEIR USE AN INHIBITORS OF INDUCIBLE NO-SYNTHASE | Aventis Pharma S.A. (FR) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003040142-A1 | 2-AMINO-4-HETEROARYLETHYL THIAZOLINE DERIVATIVES AND THEIR USE AN INHIBITORS OF INDUCIBLE NO-SYNTHASE | AVENTIS PHARMA S.A. (FR) | 2003-05-15 | — | — | WO | disclosed |