⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2880294 | 1.00 | — | — | |
| SCHEMBL14692211 | 1.00 | — | — | |
| SCHEMBL26468788 | 0.87 | — | — | |
| SCHEMBL1503804 | 0.84 | CYP1A2 (0.31) | — | |
| SCHEMBL158240 | 0.84 | CYP1A2 (0.31) | — | |
| SCHEMBL26468519 | 0.81 | CHRNB2 (0.34) | — | |
| SCHEMBL25403368 | 0.81 | — | — | |
| SCHEMBL25403790 | 0.81 | — | — | |
| SCHEMBL25334261 | 0.79 | PTPN2 (0.31) | — | |
| SCHEMBL25335341 | 0.79 | PTPN2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240091234-A1 | TREATMENT OF B-CELL MALIGNANCIES BY A COMBINATION JAK AND PI3K INHIBITORS | INCYTE CORPORATION | 2024-03-21 | — | — | US | disclosed |
| US-20230093692-A1 | C10-Alkylene Substituted 13-Membered Macrolides and Uses Thereof | ZIKANI THERAPEUTICS, INC. | 2023-03-23 | — | — | US | disclosed |
| EP-3883647-A1 | C10-ALKYLENE SUBSTITUTED 13-MEMBERED MACROLIDES AND USES THEREOF | Zikani Therapeutics, Inc. (US) | 2021-09-29 | — | — | EP | disclosed |
| EP-2822548-A1 | LONG CHAIN BASE SPHINGOSINE KINASE INHIBITORS | University Of Virginia Patent Foundation (US) | 2015-01-14 | — | — | EP | disclosed |
| EP-2742039-A1 | COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS DISEASE | F. Hoffmann-La Roche AG (CH) | 2014-06-18 | — | — | EP | disclosed |
| WO-2014022752-A1 | MACROCYCLES AS PIM INHIBITORS | AMGEN INC. (US) | 2014-02-06 | — | — | WO | disclosed |
| WO-2013119946-A1 | LONG CHAIN BASE SPHINGOSINE KINASE INHIBITORS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2013-08-15 | — | — | WO | disclosed |
| WO-2013020993-A1 | COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-02-14 | — | — | WO | disclosed |
| EP-2170073-A1 | SELECTIVE INHIBITORS FOR CYCLIN-DEPENDENT KINASES | Emory University (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008151304-A1 | SELECTIVE INHIBITORS FOR CYCLIN-DEPENDENT KINASES | EMORY UNIVERSITY (US) | 2008-12-11 | — | — | WO | disclosed |