Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.48 |
| ▸ | TEK | Q02763 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27644462 | 0.78 | KDM4E (0.48) | MEN1KMT2ANPC1RAB9AHDAC1 | |
| SCHEMBL6205740 | 0.78 | ALDH1A1 (0.53) | HSP90AB1MEN1KMT2ACASP3SENP8 | |
| SCHEMBL554725 | 0.76 | ALDH1A1 (0.64) | HSP90AB1MEN1KMT2ACASP3SENP8 | |
| SCHEMBL553844 | 0.76 | MEN1 (0.60) | HSP90AB1MEN1KMT2ACASP3SENP8 | |
| SCHEMBL27949718 | 0.75 | CA5A (0.58) | HSP90AB1HDAC1ALDH1A1LMNA | |
| Acetic Acid SCHEMBL28328686 | 0.73 | CYP19A1 (0.82) | MEN1KMT2ACASP3SENP8SENP7 | |
| SCHEMBL27850347 | 0.72 | CYP19A1 (0.58) | HSP90AB1NPC1RAB9AKDRCYP19A1 | |
| Hydrochloric Acid SCHEMBL28948699 | 0.72 | FFAR1 (0.36) | — | |
| SCHEMBL11926770 | 0.71 | CYP19A1 (0.51) | HSP90AB1MEN1KMT2ACASP3SENP8 | |
| SCHEMBL10094376 | 0.71 | HSP90AB1 (0.57) | HSP90AB1MEN1KMT2ACASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103080104-B | N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides as inhibitors of plasma kallikrein | NOVARTIS AG | 2015-04-08 | — | — | CN | disclosed |
| CN-103080104-A | N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides as inhibitors of plasma kallikrein | NOVARTIS AG | 2013-05-01 | — | — | CN | disclosed |