Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.58 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.43 |
| ▸ | PRKDC | P78527 | 4/20 | 0.43 |
| ▸ | ABL1 | P00519 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | HCK | P08631 | 3/20 | 0.43 |
| ▸ | SRC | P12931 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | MTOR | P42345 | 3/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL682446 | 0.81 | PIK3CD (0.71) | PIK3CDPIK3CGPIK3C2B | |
| SCHEMBL15169434 | 0.77 | PDE5A (0.50) | BTKLRRK2ABL1SRCMEN1 | |
| SCHEMBL2881160 | 0.76 | BTK (0.55) | BTKLRRK2PIK3CDPIK3CGPIK3CA | |
| SCHEMBL2881157 | 0.76 | BTK (0.55) | BTKLRRK2PIK3CDPIK3CGPIK3CA | |
| SCHEMBL8226946 | 0.76 | BTK (0.55) | BTKLRRK2PIK3CDPIK3CGPIK3CA | |
| SCHEMBL19727231 | 0.76 | PIK3CG (0.54) | PIK3CDPIK3CGPIK3CAPIK3CBPRKDC | |
| SCHEMBL21775364 | 0.75 | ALDH1A1 (0.41) | BTKLRRK2MEN1ALDH1A1KMT2A | |
| SCHEMBL2881164 | 0.75 | BTK (0.54) | BTKLRRK2PIK3CDPIK3CGPIK3CA | |
| SCHEMBL6868182 | 0.75 | BTK (0.62) | BTKPIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL2878149 | 0.75 | TSHR (0.47) | BTKLRRK2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004235-A1 | Heterocyclic Substituted, Anellated Pyrazole Derivative and its uses | BAYER HEALTHCARE AG (DE) | 2010-01-07 | — | — | US | disclosed |
| US-20100004235-A1 | Heterocyclic Substituted, Anellated Pyrazole Derivative and its uses | BAYER HEALTHCARE AG (DE) | 2010-01-07 | — | — | US | disclosed |
| US-20100004235-A1 | Heterocyclic Substituted, Anellated Pyrazole Derivative and its uses | BAYER HEALTHCARE AG (DE) | 2010-01-07 | — | — | US | disclosed |
| WO-2007124854-A1 | HETEROCYCLIC SUBSTITUTED, ANELLATED PYRAZOLE DERIVATIVE AND ITS USES | BAYER HEALTHCARE AG (DE) | 2007-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004235-A1 | Heterocyclic Substituted, Anellated Pyrazole Derivative and its uses | AADAC, CYP11B2, PC | BTK 3577/4885LRRK2 4503/4885PIK3CD 2681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.