SCHEMBL28808137

SCHEMBL28808137

C[Si](C)(C)Oc1cc(O)ccc1C(=O)O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.53
ESR2 Q92731 1/20 0.53
CA12 O43570 5/20 0.50
CA1 P00915 5/20 0.50
CA2 P00918 5/20 0.50
CA7 P43166 5/20 0.50
CA9 Q16790 5/20 0.50
CA14 Q9ULX7 5/20 0.50
ALDH1A1 P00352 3/20 0.50
TSHR P16473 1/20 0.50
ALOX5 P09917 1/20 0.46
PTGS2 P35354 1/20 0.46
KDM4E B2RXH2 2/20 0.41
HSD17B10 Q99714 2/20 0.41
PDK2 Q15119 1/20 0.41
PDK4 Q16654 1/20 0.41
MYC P01106 1/20 0.40
PTPN1 P18031 1/20 0.40
TDP1 Q9NUW8 2/20 0.40
POLB P06746 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL901018 0.79 ALDH1A1 (0.65) ESR1ESR2CA12CA1CA2
SCHEMBL25356108 0.77 ESR2 (0.59) ESR1ESR2CA12CA1CA2
SCHEMBL8437912 0.76 KDM4E (0.69) ESR1ESR2CA12CA1CA2
SCHEMBL7542033 0.76 KDM4E (0.58) ESR1CA12CA1CA2CA7
SCHEMBL8335667 0.75 TSHR (0.53) ESR1ESR2CA12CA1CA2
SCHEMBL27638538 0.75 ESR1 (0.53) ESR1ESR2CA12CA1CA2
SCHEMBL4776570 0.75 ALDH1A1 (0.56) ESR1ESR2CA12CA1CA2
SCHEMBL4302394 0.74 ESR1 (0.59) ESR1ESR2CA12CA1CA2
SCHEMBL6933447 0.74 ESR1 (0.51) ESR1ESR2CA12CA1CA2
SCHEMBL7565619 0.73 NPC1 (0.48) ALDH1A1ALOX5KDM4ETDP1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114854118-A Resin composition, electric wire and cable 日立金属株式会社 2022-08-05 CN disclosed