Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.54 |
| ▸ | KCNJ11 | Q14654 | 11/20 | 0.47 |
| ▸ | ABCC9 | O60706 | 6/20 | 0.47 |
| ▸ | ABCC8 | Q09428 | 6/20 | 0.47 |
| ▸ | KCNJ8 | Q15842 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3370877 | 0.80 | HPGD (0.53) | KCNJ11ABCC9ABCC8KCNJ8MEN1 | |
| SCHEMBL10587314 | 0.79 | KDM4E (0.46) | KCNJ11ABCC9ABCC8KCNJ8MEN1 | |
| SCHEMBL15414915 | 0.79 | NCEH1 (0.58) | NCEH1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1994212 | 0.78 | CA12 (0.55) | KDM4ENOTUMALDH1A1HPGDLMNA | |
| SCHEMBL14052468 | 0.77 | BACE1 (0.47) | NCEH1KCNJ11TRPV1LMNAMAPK1 | |
| SCHEMBL12985269 | 0.77 | KCNJ11 (0.42) | NCEH1KCNJ11ABCC9ABCC8KCNJ8 | |
| SCHEMBL1638703 | 0.77 | CA12 (0.60) | NCEH1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL71131 | 0.77 | NCEH1 (0.59) | NCEH1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL29404644 | 0.77 | NCEH1 (0.59) | NCEH1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1648076 | 0.77 | NCEH1 (0.59) | NCEH1MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103443099-A | Compositions and methods for modulating FXR | IRM LLC | 2013-12-11 | — | — | CN | disclosed |
| CN-103370315-A | Compositions and methods for modulating farnesoid x receptors | IRM LLC | 2013-10-23 | — | — | CN | disclosed |