Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27832442 | 0.86 | TDP1 (0.44) | MAPK1TSHRTDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9597051 | 0.80 | TSHR (0.51) | MAPK1TSHRTDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL21580855 | 0.79 | TSHR (0.47) | MAPK1TSHRTDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7678122 | 0.79 | TSHR (0.50) | MAPK1TSHRTDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7684234 | 0.78 | MAPK1 (0.44) | MAPK1TSHRTDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL21580836 | 0.77 | TSHR (0.51) | MAPK1TSHRTDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL27559947 | 0.76 | L3MBTL1 (0.48) | MAPK1TSHRTDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL28965318 | 0.76 | ABCB1 (0.42) | MAPK1ALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL7678123 | 0.75 | MAPK1 (0.46) | MAPK1TSHRTDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7678134 | 0.75 | MAPK1 (0.46) | MAPK1TSHRTDP1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114853730-A | Compound used as HPK1 kinase inhibitor and preparation method and application thereof | 中国药科大学 | 2022-08-05 | — | — | CN | disclosed |