Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7677021 | 0.89 | LMNA (0.48) | MAPK1TSHRTDP1LMNASMN1; SMN2 | |
| SCHEMBL9597051 | 0.80 | TSHR (0.51) | MAPK1TSHRTDP1LMNASMN1; SMN2 | |
| SCHEMBL28811394 | 0.78 | MAPK1 (0.44) | MAPK1TSHRTDP1LMNASMN1; SMN2 | |
| SCHEMBL7684124 | 0.78 | ELANE (0.46) | MAPK1TSHRTDP1LMNAALDH1A1 | |
| SCHEMBL7673650 | 0.77 | LMNA (0.47) | MAPK1TSHRTDP1LMNASMN1; SMN2 | |
| SCHEMBL21580836 | 0.77 | TSHR (0.51) | MAPK1TSHRTDP1LMNASMN1; SMN2 | |
| SCHEMBL27559947 | 0.76 | L3MBTL1 (0.48) | MAPK1TSHRTDP1LMNASMN1; SMN2 | |
| SCHEMBL21580855 | 0.76 | TSHR (0.47) | MAPK1TSHRTDP1LMNASMN1; SMN2 | |
| SCHEMBL7683802 | 0.76 | ABCB1 (0.40) | TSHRTDP1POLBALDH1A1MEN1 | |
| SCHEMBL7678122 | 0.76 | TSHR (0.50) | MAPK1TSHRTDP1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6469181-B1 | PREPARING 2-OXINDOLES AND N-HYROXY-2- OXINDOLES VIA REDUCTION OF 2-NITROARYLMALONATE DIESTERS WITHOUT ISOLATION OF INTERMEDIATES | CATALYTICA, INC. | 2002-10-22 | — | — | US | disclosed |
| EP-0809631-A4 | PROCESS FOR PREPARING 2-OXINDOLES AND N-HYDROXY-2-OXINDOLES | CATALYTICA INC (US) | 1998-07-08 | — | — | EP | disclosed |
| EP-0809631-A1 | PROCESS FOR PREPARING 2-OXINDOLES AND N-HYDROXY-2-OXINDOLES | CATALYTICA, INC. (US) | 1997-12-03 | — | — | EP | disclosed |
| WO-1996023770-A1 | PROCESS FOR PREPARING 2-OXINDOLES AND N-HYDROXY-2-OXINDOLES | CATALYTICA, INC. (US) | 1996-08-08 | — | — | WO | disclosed |