Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | CNR2 | P34972 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | TSPO | P30536 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3805659 | 0.82 | POLB (0.56) | POLBCNR2MAPTFOLH1LMNA | |
| SCHEMBL28812043 | 0.80 | POLB (0.54) | POLBMAPTFOLH1LMNAGLA | |
| SCHEMBL8857042 | 0.75 | FOLH1 (0.70) | POLBFOLH1MCL1TP53 | |
| SCHEMBL27704791 | 0.73 | POLB (0.51) | POLBCNR2MAPTLMNAGLA | |
| SCHEMBL27617372 | 0.73 | FOLH1 (0.52) | POLBFOLH1MCL1TP53 | |
| SCHEMBL3669231 | 0.71 | POLB (0.64) | POLBMAPTFOLH1LMNAGLA | |
| SCHEMBL3296485 | 0.71 | F10 (0.54) | POLBMAPTF10 | |
| SCHEMBL7744033 | 0.70 | F10 (0.56) | MAPTFOLH1F10 | |
| SCHEMBL8857055 | 0.70 | FOLH1 (0.62) | CNR2FOLH1MCL1TP53 | |
| SCHEMBL5277418 | 0.69 | KDM4E (0.60) | POLBCNR2MAPTFOLH1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101511819-B | Derivatives of N- (amino-heteroaryl) -1H-indole-2-amides, preparation thereof and use thereof in therapy | SANOFI AVENTIS | 2014-04-23 | — | — | CN | disclosed |