Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | FOLH1 | Q04609 | 5/20 | 0.53 |
| ▸ | CCR2 | P41597 | 2/20 | 0.50 |
| ▸ | FABP3 | P05413 | 1/20 | 0.49 |
| ▸ | FABP4 | P15090 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28812043 | 0.89 | POLB (0.54) | POLBFOLH1MAPTALDH1A1NPSR1 | |
| SCHEMBL3805659 | 0.79 | POLB (0.56) | POLBFOLH1MAPTALDH1A1NPSR1 | |
| SCHEMBL926655 | 0.78 | POLB (0.57) | POLBFOLH1CCR2FABP3MAPT | |
| SCHEMBL939555 | 0.75 | POLB (0.45) | POLBFABP3FABP4MAPTALDH1A1 | |
| SCHEMBL4551188 | 0.75 | CCR2 (0.56) | POLBCCR2FABP3FABP4 | |
| SCHEMBL940545 | 0.74 | POLB (0.46) | POLBFABP3FABP4MAPTALDH1A1 | |
| SCHEMBL27811964 | 0.73 | CCR2 (0.76) | POLBCCR2ALDH1A1 | |
| SCHEMBL5011320 | 0.72 | MAPT (0.60) | POLBMAPTALDH1A1NPSR1MEN1 | |
| SCHEMBL28811490 | 0.71 | POLB (0.53) | POLBFOLH1MAPTLMNAGLA | |
| SCHEMBL14809705 | 0.71 | CCR2 (0.70) | POLBFOLH1CCR2FABP4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2235003-A1 | DERIVATIVES OF INDOLE 2-CARBOXAMIDES AND AZAINDOLE 2-CARBOXAMIDES SUBSTITUTED BY A SILANYLE GROUP, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009109710-A1 | DERIVATIVES OF INDOLE 2-CARBOXAMIDES AND AZAINDOLE 2-CARBOXAMIDES SUBSTITUTED BY A SILANYLE GROUP, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-09-11 | — | — | WO | disclosed |