Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 5/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | TSPO | P30536 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3669231 | 0.89 | POLB (0.64) | POLBMAPTALDH1A1NPSR1IDO1 | |
| SCHEMBL3805659 | 0.88 | POLB (0.56) | POLBMAPTALDH1A1NPSR1F10 | |
| SCHEMBL28811490 | 0.80 | POLB (0.53) | POLBMAPTF10LMNAGLA | |
| SCHEMBL3296485 | 0.76 | F10 (0.54) | POLBMAPTALDH1A1NPSR1F10 | |
| SCHEMBL3647083 | 0.73 | PLA2G10 (0.71) | POLBF10IDO1LMNAGLA | |
| SCHEMBL7744033 | 0.70 | F10 (0.56) | MAPTALDH1A1F10SMN1; SMN2FOLH1 | |
| SCHEMBL29015820 | 0.69 | FOLH1 (0.49) | POLBMAPTALDH1A1F10LMNA | |
| SCHEMBL3300405 | 0.69 | F10 (0.47) | POLBF10IDO1 | |
| SCHEMBL926655 | 0.69 | POLB (0.57) | POLBMAPTIDO1TDP1FOLH1 | |
| SCHEMBL4551188 | 0.69 | CCR2 (0.56) | POLBF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102143956-B | Derivatives of indole-2-carboxamides and azaindole-2-carboxamides substituted by silane groups, preparation thereof and therapeutic use thereof | SANOFI AVENTIS | 2014-04-23 | — | — | CN | disclosed |