Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 2/20 | 0.50 |
| ▸ | PPARA | Q07869 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | LPL | P06858 | 1/20 | 0.47 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL167733 | 0.91 | TAAR1 (0.61) | TAAR1NPC1RAB9AHPGDLPL | |
| SCHEMBL30869992 | 0.91 | TAAR1 (0.61) | TAAR1NPC1RAB9AHPGDLPL | |
| Phenol SCHEMBL28185005 | 0.86 | DRD2 (0.54) | TAAR1NPC1RAB9AHPGDLPL | |
| Butyl Alcohol SCHEMBL27857142 | 0.86 | TAAR1 (0.52) | TAAR1NPC1RAB9AHPGDLPL | |
| SCHEMBL598872 | 0.85 | TAAR1 (0.59) | TAAR1PPARGPPARALPLLIPG | |
| SCHEMBL8096717 | 0.84 | TAAR1 (0.53) | TAAR1NPC1RAB9AHPGDLPL | |
| SCHEMBL9485795 | 0.83 | LPL (0.59) | TAAR1PPARGPPARALPLLIPG | |
| SCHEMBL8780379 | 0.83 | LPL (0.59) | TAAR1PPARGPPARALPLLIPG | |
| SCHEMBL105418 | 0.83 | LPL (0.59) | TAAR1PPARGPPARALPLLIPG | |
| SCHEMBL11073651 | 0.83 | LPL (0.59) | TAAR1PPARGPPARALPLLIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102753516-B | Process for producing diaryl carbonate | ASAHI KASEI CHEMICALS CORP | 2015-04-01 | — | — | CN | disclosed |
| CN-102753508-B | Method for producing aryloxy titanium composition, and aryloxy titanium composition | ASAHI CHEMICAL CORP | 2014-12-10 | — | — | CN | disclosed |