Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.35 |
| ▸ | CACNA1I | Q9P0X4 | 6/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 3/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | CCR2 | P41597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27985537 | 0.81 | KDM4E (0.40) | KCNH2PDK1KDM4EDRD3CCR2 | |
| SCHEMBL19998542 | 0.74 | KDM1A (0.44) | SMN1; SMN2PDK1DRD3SIGMAR1 | |
| SCHEMBL27985446 | 0.73 | PDK1 (0.35) | SMN1; SMN2PDK1 | |
| SCHEMBL14940873 | 0.72 | MEN1 (0.33) | SMN1; SMN2MEN1KMT2AOPRM1OPRL1 | |
| SCHEMBL14940870 | 0.72 | SMN1; SMN2 (0.30) | SMN1; SMN2MEN1KMT2AOPRM1OPRL1 | |
| SCHEMBL25565630 | 0.71 | CACNA1H (0.33) | CACNA1HDRD3 | |
| SCHEMBL25565628 | 0.71 | CACNA1H (0.33) | CACNA1HDRD3 | |
| SCHEMBL24692721 | 0.68 | PDK1 (0.32) | PDK1CACNA1HDRD3 | |
| SCHEMBL28199158 | 0.67 | ALDH1A1 (0.42) | KCNH2MEN1KMT2APDK1KDM4E | |
| SCHEMBL12788557 | 0.67 | TSHR (0.55) | SMN1; SMN2MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104105691-A | MODULATORS OF THE G PROTEIN-COUPLED MAS RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC | 2014-10-15 | — | — | CN | disclosed |