Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3067831 | 1.00 | PDE4A (0.59) | PDE4ALMNATDP1L3MBTL1USP2 | |
| SCHEMBL19952978 | 1.00 | PDE4A (0.59) | PDE4ALMNATDP1L3MBTL1USP2 | |
| SCHEMBL19952979 | 1.00 | PDE4A (0.59) | PDE4ALMNATDP1L3MBTL1USP2 | |
| SCHEMBL258100 | 1.00 | PDE4A (0.59) | PDE4ALMNATDP1L3MBTL1USP2 | |
| SCHEMBL29563836 | 1.00 | PDE4A (0.59) | PDE4ALMNATDP1L3MBTL1USP2 | |
| SCHEMBL2135451 | 0.92 | PDE4A (0.55) | PDE4ALMNATDP1L3MBTL1USP2 | |
| SCHEMBL887710 | 0.92 | PDE4A (0.55) | PDE4ALMNATDP1L3MBTL1USP2 | |
| SCHEMBL3764484 | 0.82 | PDE4A (0.44) | PDE4ALMNATDP1L3MBTL1USP2 | |
| SCHEMBL14940504 | 0.82 | PDE4A (0.44) | PDE4ALMNATDP1L3MBTL1USP2 | |
| SCHEMBL677609 | 0.82 | PDE4A (0.44) | PDE4ALMNATDP1L3MBTL1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427446-A1 | INHIBITORS OF SIALIDASE OR SIALIDASE-LIKE ENZYMES | National Research Council of Canada (CA) | 2012-03-14 | — | — | EP | claimed |
| WO-2010127443-A1 | INHIBITORS OF SIALIDASE OR SIALIDASE-LIKE ENZYMES | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2010-11-11 | — | — | WO | claimed |
| EP-2427446-A1 | INHIBITORS OF SIALIDASE OR SIALIDASE-LIKE ENZYMES | National Research Council of Canada (CA) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010127443-A1 | INHIBITORS OF SIALIDASE OR SIALIDASE-LIKE ENZYMES | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2010-11-11 | — | — | WO | disclosed |