Trifluoromethylbenzene

Trifluoromethylbenzene

SCHEMBL28815330

FC(F)(F)c1ccccc1.Nc1nc(Cl)nc(Cl)n1

nearest known ligand 0.54

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.54
TSHR P16473 2/20 0.54
ADORA2A P29274 3/20 0.43
ADORA1 P30542 2/20 0.43
KDM4E B2RXH2 3/20 0.42
LMNA P02545 2/20 0.42
GLA P06280 1/20 0.42
HPGD P15428 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
APP P05067 2/20 0.42
HSD17B10 Q99714 1/20 0.42
KIF11 P52732 1/20 0.42
MAPK1 P28482 1/20 0.39
MAPT P10636 1/20 0.39
CYP19A1 P11511 1/20 0.39
GRM4 Q14833 1/20 0.38
HSP90AA1 P07900 1/20 0.38
HSP90AB1 P08238 1/20 0.38
DPP4 P27487 1/20 0.38
IDH2 P48735 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoromethylbenzene SCHEMBL28051440 0.86 TSHR (0.67) ALDH1A1TSHRADORA2AADORA1KDM4E
Trifluoromethylbenzene SCHEMBL27916783 0.85 LMNA (0.50) ALDH1A1TSHRKDM4ELMNAHPGD
Trifluoromethylbenzene SCHEMBL27850302 0.82 KDM4E (0.48) ALDH1A1TSHRADORA2AADORA1KDM4E
Trifluoromethylbenzene SCHEMBL27935510 0.81 LMNA (0.47) KDM4ELMNAHPGDSMN1; SMN2APP
Trifluoromethylbenzene SCHEMBL28797174 0.80 APP (0.53) ALDH1A1KDM4ELMNAHPGDAPP
Trifluoromethylbenzene SCHEMBL2169987 0.76 TSHR (0.93) ALDH1A1TSHRKIF11MAPK1MAPT
Trifluoromethylbenzene SCHEMBL8863222 0.76 TSHR (0.93) ALDH1A1TSHRKIF11MAPK1MAPT
Trifluoromethylbenzene SCHEMBL28037899 0.74 TSHR (0.56) ALDH1A1TSHRADORA2AADORA1KDM4E
Trifluoromethylbenzene SCHEMBL28143223 0.73 TSHR (0.88) ALDH1A1TSHRKIF11MAPK1CYP19A1
Trifluoromethylbenzene SCHEMBL4867878 0.73 TSHR (0.88) ALDH1A1TSHRKIF11MAPK1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102442960-B Cyanuric chloride derivative as well as preparation method and application thereof WUHAN INST TECHNOLOGY 2014-12-24 CN claimed
CN-102442960-B Cyanuric chloride derivative as well as preparation method and application thereof WUHAN INST TECHNOLOGY 2014-12-24 CN disclosed