Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 7/20 | 0.38 |
| ▸ | GRM5 | P41594 | 6/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23164876 | 0.92 | GPR119 (0.55) | GPR119JAK1GRM1GRM5NAMPT | |
| SCHEMBL28816321 | 0.80 | NAMPT (0.40) | GPR119JAK1GRM1GRM5NAMPT | |
| SCHEMBL21045911 | 0.74 | GRM1 (0.42) | JAK1GRM1GRM5NAMPTPDK4 | |
| SCHEMBL2358167 | 0.73 | GPR119 (0.59) | GPR119JAK1GRM1GRM5NAMPT | |
| SCHEMBL31705807 | 0.73 | GPR119 (0.56) | GPR119JAK1GRM1GRM5NAMPT | |
| SCHEMBL31705435 | 0.73 | GPR119 (0.56) | GPR119JAK1GRM1GRM5NAMPT | |
| SCHEMBL31341012 | 0.72 | CDK5 (0.57) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL30926321 | 0.72 | GPR119 (0.61) | GPR119JAK1GRM1GRM5NAMPT | |
| SCHEMBL2357493 | 0.72 | GPR119 (0.57) | GPR119GRM1GRM5NAMPTPDK4 | |
| SCHEMBL23164675 | 0.71 | NAMPT (0.49) | GPR119JAK1GRM1GRM5NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114761404-A | Substituted bicyclic heteroaryl compounds | 百时美施贵宝公司 | 2022-07-15 | — | — | CN | disclosed |