Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | UBE2T | Q9NPD8 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 3/20 | 0.36 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.35 |
| ▸ | C1S | P09871 | 1/20 | 0.35 |
| ▸ | F12 | P00748 | 1/20 | 0.33 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
| ▸ | F3 | P13726 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | MASP2 | O00187 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1828070 | 0.79 | NNMT (0.44) | BACE1LMNA | |
| SCHEMBL30445761 | 0.79 | NNMT (0.44) | BACE1LMNA | |
| SCHEMBL30936080 | 0.77 | F10 (0.33) | UBE2TF2F10PRSS1PRSS2 | |
| SCHEMBL30721127 | 0.72 | HCAR2 (0.50) | LMNA | |
| SCHEMBL898595 | 0.72 | HCAR2 (0.50) | LMNA | |
| SCHEMBL20577332 | 0.71 | BACE1 (0.33) | BACE1 | |
| SCHEMBL12634680 | 0.70 | CES2 (0.50) | F2F10PRSS1PRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL5115579 | 0.69 | CES2 (0.48) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL20554192 | 0.68 | UBE2T (0.49) | UBE2TF2F10PRSS1PRSS3 | |
| SCHEMBL8005179 | 0.68 | HCAR2 (0.55) | F2F10PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104302626-A | 4, 4-disubstituted-1, 4-dihydropyrimidines and their use as medicaments for the treatment of hepatitis b | JANSSEN R & D IRELAND | 2015-01-21 | — | — | CN | disclosed |