Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 2/20 | 0.42 |
| ▸ | VNN1 | O95497 | 1/20 | 0.42 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | STAMBP | O95630 | 1/20 | 0.40 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30445761 | 1.00 | NNMT (0.44) | NNMTSMN1; SMN2HPGDSVNN1PSMD14 | |
| SCHEMBL23203545 | 0.82 | NNMT (0.47) | NNMTSMN1; SMN2HPGDSVNN1PSMD14 | |
| SCHEMBL898595 | 0.81 | HCAR2 (0.50) | SMN1; SMN2VNN1PSMD14LMNAKDM4E | |
| SCHEMBL30721127 | 0.81 | HCAR2 (0.50) | SMN1; SMN2VNN1PSMD14LMNAKDM4E | |
| SCHEMBL13465582 | 0.80 | LMNA (0.42) | NNMTSMN1; SMN2HPGDSPSMD14STAMBP | |
| SCHEMBL26337535 | 0.80 | LMNA (0.42) | NNMTSMN1; SMN2HPGDSVNN1PSMD14 | |
| SCHEMBL28817028 | 0.79 | BACE1 (0.40) | BACE1LMNA | |
| SCHEMBL12350329 | 0.79 | NNMT (0.40) | NNMTSMN1; SMN2HPGDSVNN1PSMD14 | |
| SCHEMBL31575526 | 0.77 | VNN1 (0.40) | NNMTSMN1; SMN2HPGDSVNN1PSMD14 | |
| SCHEMBL13394495 | 0.76 | NNMT (0.39) | NNMTSMN1; SMN2HPGDSPSMD14STAMBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318416-A1 | SPIROAMINODIHYDROTHIAZINE DERIVATIVES | Eisai R&D Management Co., Ltd. (JP) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010013794-A1 | SPIROAMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-02-04 | — | — | WO | disclosed |
| EP-1246802-A1 | 4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES | Dow Agrosciences LLC (US) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001051468-A1 | 4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES | DOW AGROSCIENCES LLC (US) | 2001-07-19 | — | — | WO | disclosed |