Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.32 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylamide SCHEMBL35701 | 0.96 | TSHR (0.48) | TSHRALDH1A1FGFR4LMNASLC6A6 | |
| Acrylamide SCHEMBL26616208 | 0.94 | TSHR (0.46) | TSHRALDH1A1FGFR4LMNASLC6A6 | |
| Acrylamide SCHEMBL27699998 | 0.94 | TSHR (0.46) | TSHRALDH1A1FGFR4LMNASLC6A6 | |
| Acrylamide SCHEMBL2099416 | 0.84 | TSHR (0.44) | TSHRALDH1A1FGFR4LMNASLC6A6 | |
| SCHEMBL28481099 | 0.83 | LMNA (0.43) | TSHRALDH1A1LMNASLC6A6CYP2C19 | |
| Acrylamide SCHEMBL2102098 | 0.83 | ALDH1A1 (0.58) | TSHRALDH1A1FGFR4LMNASLC6A6 | |
| Acrylamide SCHEMBL29113062 | 0.82 | TSHR (0.42) | TSHRALDH1A1FGFR4LMNASLC6A6 | |
| Acrylamide SCHEMBL2099370 | 0.82 | EPHX2 (0.49) | TSHRALDH1A1FGFR4CYP2C19EPHX2 | |
| Acrylamide SCHEMBL28005524 | 0.82 | TSHR (0.42) | TSHRALDH1A1FGFR4LMNASLC6A6 | |
| Acrylic Acid SCHEMBL766910 | 0.81 | LMNA (0.46) | TSHRALDH1A1LMNASLC6A6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104519856-A | Two-phase cosmetic composition and pump bottle containing same | OREAL | 2015-04-15 | — | — | CN | disclosed |