Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29785533 | 1.00 | LMNA (0.48) | LMNAPOLBALDH1A1HTTNPC1 | |
| SCHEMBL28817644 | 1.00 | LMNA (0.48) | LMNAPOLBALDH1A1HTTNPC1 | |
| SCHEMBL29785613 | 1.00 | LMNA (0.48) | LMNAPOLBALDH1A1HTTNPC1 | |
| SCHEMBL28817594 | 1.00 | LMNA (0.48) | LMNAPOLBALDH1A1HTTNPC1 | |
| SCHEMBL28817620 | 0.83 | LMNA (0.45) | LMNAPOLBALDH1A1HTTNPC1 | |
| SCHEMBL29785674 | 0.83 | LMNA (0.45) | LMNAPOLBALDH1A1HTTNPC1 | |
| SCHEMBL28817629 | 0.76 | KMT2A (0.46) | LMNAALDH1A1HTTKMT2ADRD3 | |
| SCHEMBL28817670 | 0.76 | KMT2A (0.46) | LMNAALDH1A1HTTKMT2ADRD3 | |
| SCHEMBL28817632 | 0.76 | KMT2A (0.46) | LMNAALDH1A1HTTKMT2ADRD3 | |
| SCHEMBL3132074 | 0.76 | DRD2 (0.49) | POLBALDH1A1KMT2AGAADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114763357-B | Indolopyrimidine tricyclic compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2024-06-18 | — | — | CN | disclosed |
| CN-114763357-A | Indolopyrimidine tricyclic compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2022-07-19 | — | — | CN | disclosed |