Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | DRD1 | P21728 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28817670 | 1.00 | KMT2A (0.46) | KMT2AOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL28817632 | 1.00 | KMT2A (0.46) | KMT2AOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL29785584 | 0.79 | OPRM1 (0.42) | KMT2AOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL28817599 | 0.76 | LMNA (0.48) | KMT2ADRD3MEN1ALDH1A1LMNA | |
| SCHEMBL29785613 | 0.76 | LMNA (0.48) | KMT2ADRD3MEN1ALDH1A1LMNA | |
| SCHEMBL28817594 | 0.76 | LMNA (0.48) | KMT2ADRD3MEN1ALDH1A1LMNA | |
| SCHEMBL29785533 | 0.76 | LMNA (0.48) | KMT2ADRD3MEN1ALDH1A1LMNA | |
| SCHEMBL28817644 | 0.76 | LMNA (0.48) | KMT2ADRD3MEN1ALDH1A1LMNA | |
| SCHEMBL3137205 | 0.76 | KMT2A (0.46) | KMT2AOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL29785592 | 0.74 | OPRM1 (0.46) | KMT2AOPRM1OPRD1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114763357-B | Indolopyrimidine tricyclic compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2024-06-18 | — | — | CN | disclosed |
| CN-114763357-A | Indolopyrimidine tricyclic compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2022-07-19 | — | — | CN | disclosed |