Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 14/20 | 0.70 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9555 | 0.84 | NOTUM (1.00) | NOTUMTLR8TSHRKDM4EALDH1A1 | |
| Biphenyl SCHEMBL22577775 | 0.82 | NOTUM (0.95) | NOTUMTLR8TSHRKDM4EALDH1A1 | |
| SCHEMBL5571187 | 0.80 | NOTUM (0.91) | NOTUMTLR8TSHRKDM4EALDH1A1 | |
| Acetamide SCHEMBL28274790 | 0.78 | NOTUM (0.72) | NOTUMTLR8TSHRKDM4EALDH1A1 | |
| SCHEMBL6851980 | 0.75 | NOTUM (0.58) | NOTUMTLR8TSHRTP53KDM4E | |
| Ethoxycarbonyl Group SCHEMBL27868448 | 0.75 | NOTUM (0.62) | NOTUMTLR8TSHRTP53KDM4E | |
| SCHEMBL3970760 | 0.74 | NOTUM (0.78) | NOTUMTLR8TSHRKDM4EALDH1A1 | |
| Biphenyl SCHEMBL29204213 | 0.73 | ALDH1A1 (0.50) | NOTUMTP53ALDH1A1LMNAMAPT | |
| SCHEMBL17694561 | 0.73 | NOTUM (0.78) | NOTUMTLR8TSHRTP53KDM4E | |
| SCHEMBL17197374 | 0.72 | NOTUM (0.74) | NOTUMTLR8TSHRTP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104736535-A | Heterocyclic modulators of hif activity for treatment of disease | JONES PHILIP | 2015-06-24 | — | — | CN | disclosed |