Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 9/20 | 0.62 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethoxycarbonyl Group SCHEMBL27933392 | 0.87 | NOTUM (0.66) | NOTUMTLR8ALDH1A1SMN1; SMN2MEN1 | |
| Ethoxycarbonyl Group SCHEMBL29082677 | 0.86 | NOTUM (0.47) | NOTUMTLR8ALDH1A1SMN1; SMN2MEN1 | |
| Ethoxycarbonyl Group SCHEMBL28826453 | 0.86 | NOTUM (0.48) | NOTUMTLR8ALDH1A1TP53PTGS2 | |
| Ethoxycarbonyl Group SCHEMBL27921877 | 0.85 | PTGS2 (0.50) | NOTUMTLR8ALDH1A1SMN1; SMN2TP53 | |
| Ethoxycarbonyl Group SCHEMBL28826450 | 0.82 | NOTUM (0.47) | NOTUMTLR8ALDH1A1TP53TSHR | |
| Ethoxycarbonyl Group SCHEMBL27851503 | 0.80 | TSHR (0.44) | NOTUMTLR8ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL9555 | 0.79 | NOTUM (1.00) | NOTUMTLR8ALDH1A1SMN1; SMN2TSHR | |
| Ethoxycarbonyl Group SCHEMBL28264125 | 0.77 | SMN1; SMN2 (0.35) | NOTUMALDH1A1SMN1; SMN2MEN1KMT2A | |
| Biphenyl SCHEMBL22577775 | 0.77 | NOTUM (0.95) | NOTUMTLR8ALDH1A1SMN1; SMN2TSHR | |
| Biphenyl SCHEMBL27961596 | 0.77 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2MEN1KMT2APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103209979-B | therapeutic agent 976 | ASTRAZENECA AB (SE) | 2016-02-10 | — | — | CN | disclosed |
| CN-103936751-A | Compound, preparation method and application thereof, and pharmaceutical composition having the same | ASTRAZENECA AB | 2014-07-23 | — | — | CN | disclosed |
| CN-102459279-B | Therapeutic agents 713 | ASTRAZENECA AB | 2014-06-25 | — | — | CN | disclosed |
| CN-103209979-A | Therapeutic agent 976 | ASTRAZENECA AB | 2013-07-17 | — | — | CN | disclosed |
| CN-102459279-A | Therapeutic agents 713 | ASTRAZENECA AB | 2012-05-16 | — | — | CN | disclosed |