SCHEMBL2882005

SCHEMBL2882005

CCC(Oc1ccc(-c2ccc(S(C)(=O)=O)cc2)nc1)C1CCN(C(=O)OC(C)CI)CC1

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 20/20 0.49
GPR183 P32249 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL386769 0.92 GPR119 (0.56) GPR119
SCHEMBL388367 0.92 GPR119 (0.56) GPR119
SCHEMBL387411 0.92 GPR119 (0.56) GPR119
SCHEMBL387399 0.83 GPR119 (0.60) GPR119
SCHEMBL388696 0.83 GPR119 (0.60) GPR119
SCHEMBL387537 0.83 GPR119 (0.45) GPR119GPR183
SCHEMBL2876152 0.82 GPR119 (0.51) GPR119
SCHEMBL3845663 0.80 GPR119 (0.53) GPR119GPR183
SCHEMBL388632 0.78 GPR119 (0.69) GPR119GPR183
SCHEMBL387326 0.76 GPR119 (0.47) GPR119GPR183

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2010512334-A 2010-04-22 JP claimed
EP-2094683-A2 BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS SmithKline Beecham Corporation (US) 2009-09-02 EP claimed
WO-2008070692-A2 BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS SMITHKLINE BEECHAM CORPORATION (US) 2008-06-12 WO claimed