Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethyl Sulfoxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 13/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.84 |
| ▸ | MAPT | P10636 | 5/20 | 0.84 |
| ▸ | MEN1 | O00255 | 5/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.84 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.84 |
| ▸ | HPGD | P15428 | 2/20 | 0.84 |
| ▸ | RAF1 | P04049 | 1/20 | 0.84 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.68 |
| ▸ | PKM | P14618 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.68 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL157490 | 0.92 | AR (1.00) | ARCYP3A4MAPTMEN1KMT2A | |
| SCHEMBL12636899 | 0.83 | AR (1.00) | ARCYP3A4MAPTMEN1KMT2A | |
| Chrysin SCHEMBL5461671 | 0.82 | CYP3A4 (0.82) | ARCYP3A4MAPTMEN1KMT2A | |
| 5-Hydroxyflavone SCHEMBL30630415 | 0.81 | AR (1.00) | ARCYP3A4MAPTMEN1KMT2A | |
| 5-Hydroxyflavone SCHEMBL158303 | 0.81 | AR (1.00) | ARCYP3A4MAPTMEN1KMT2A | |
| 5-Hydroxyflavone SCHEMBL2390993 | 0.81 | AR (1.00) | ARCYP3A4MAPTMEN1KMT2A | |
| SCHEMBL6097859 | 0.80 | AR (1.00) | ARCYP3A4MAPTMEN1KMT2A | |
| 5-Hydroxyflavone SCHEMBL28317755 | 0.80 | AR (0.97) | ARCYP3A4MAPTMEN1KMT2A | |
| 5-Hydroxyflavone SCHEMBL2390943 | 0.80 | AR (0.97) | ARCYP3A4MAPTMEN1KMT2A | |
| SCHEMBL1764307 | 0.80 | MAOB (0.78) | ARCYP3A4MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104839158-A | Preparation method of flavone sustained-release algal inhibition preparation | UNIV ZHEJIANG | 2015-08-19 | — | — | CN | disclosed |