5-Hydroxyflavone

5-Hydroxyflavone

SCHEMBL158303

O=c1cc(-c2ccccc2)oc2cccc(O)c12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 13/20 1.00
CYP3A4 P08684 7/20 1.00
MAPT P10636 7/20 1.00
MEN1 O00255 5/20 1.00
KMT2A Q03164 5/20 1.00
ALDH1A1 P00352 3/20 1.00
CYP1A1 P04798 3/20 1.00
CYP1A2 P05177 3/20 1.00
ALOX15 P16050 3/20 1.00
SMN1; SMN2 Q16637 3/20 1.00
CYP1B1 Q16678 3/20 1.00
FTO Q9C0B1 3/20 1.00
PKM P14618 1/20 1.00
MAPK1 P28482 3/20 0.79
HPGD P15428 3/20 0.79
RAF1 P04049 1/20 0.79
CYP2C9 P11712 4/20 0.72
CYP2C19 P33261 4/20 0.72
KDM4E B2RXH2 3/20 0.72
HSD17B10 Q99714 3/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
5-Hydroxyflavone SCHEMBL2390993 1.00 AR (1.00) ARCYP3A4MAPTMEN1KMT2A
5-Hydroxyflavone SCHEMBL30630415 1.00 AR (1.00) ARCYP3A4MAPTMEN1KMT2A
5-Hydroxyflavone SCHEMBL2390943 0.98 AR (0.97) ARCYP3A4MAPTMEN1KMT2A
5-Hydroxyflavone SCHEMBL28317755 0.98 AR (0.97) ARCYP3A4MAPTMEN1KMT2A
5-Hydroxyflavone SCHEMBL27873127 0.94 AR (0.88) ARCYP3A4MAPTMEN1KMT2A
5-Hydroxyflavone SCHEMBL27861570 0.93 AR (0.86) ARCYP3A4MAPTMEN1KMT2A
SCHEMBL6094870 0.92 CYP3A4 (0.85) ARCYP3A4MAPTMEN1KMT2A
SCHEMBL157490 0.89 AR (1.00) ARCYP3A4MAPTMEN1KMT2A
Chrysin SCHEMBL5461671 0.88 CYP3A4 (0.82) ARCYP3A4MAPTMEN1KMT2A
SCHEMBL4649971 0.87 CYP3A4 (1.00) ARCYP3A4MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1419 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4698662-A2 REGULATABLE CONTROLLED EXPRESSION OF A TRANSGENE IN PRIMATES AskBio Inc. (US) 2026-02-25 EP claimed
EP-2603098-B1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER FIRMENICH INCORPORATED (US) 2025-08-06 EP claimed
WO-2024220449-A9 REGULATABLE CONTROLLED EXPRESSION OF A TRANSGENE IN PRIMATES AskBio Inc. (US) 2025-04-03 WO claimed
US-20250011393-A1 FLAVONOID-COLLAGEN CROSSLINKED ANTIOXIDANT HYDROGEL NORTH CAROLINA STATE UNIVERSITY 2025-01-09 US claimed
WO-2024220449-A2 REGULATABLE CONTROLLED EXPRESSION OF A TRANSGENE IN PRIMATES ASKLEPIOS BIOPHARMACEUTICAL, INC. (US) 2024-10-24 WO claimed
US-20240315965-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2024-09-26 US claimed
CN-118518860-A Biomarker for diagnosing or early warning acute coronary syndrome, screening method and application thereof 山东第一医科大学(山东省医学科学院) 2024-08-20 CN claimed
CN-117618647-A Anti-infection bone repair promoting preparation for sequentially regulating and controlling macrophage immune microenvironment and preparation method thereof 广东省科学院微生物研究所(广东省微生物分析检测中心) 2024-03-01 CN claimed
WO-2023150072-A1 COMPOSITIONS AND METHODS FOR THE PRESERVATION OF PLANT MATTER SINCLAIR DAVID A (US) 2023-08-10 WO claimed
US-20230119060-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER CONTAINING, AS ACTIVE INGREDIENT, COMPLEX OF BIGUANIDE-BASED COMPOUND AND FLAVONE, HYDROXYFLAVONE, FLAVANONE, FLAVONE DERIVATIVE, HYDROXYFLAVONE DERIVATIVE, OR FLAVANONE DERIVATIVE MEDIENCE CO., LTD. (KR) 2023-04-20 US claimed
US-20040265253-A1 Organic-inorganic hybrid material, composition for synthesizing the same, and manufacturing method of the same SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2004-12-30 US claimed
US-20040091589-A1 Prevention of synthetic color fading in beverages using botanically derived color stabilizers PEPSICO, INC. 2004-05-13 US claimed
US-20030170495-A1 Organic electroluminescent device SANYO ELECTRIC CO., LTD. (JP) 2003-09-11 US claimed
JP-2003504327-A 2003-02-04 JP claimed
EP-1223928-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS Prendergast, Patrick Thomas (IE) 2002-07-24 EP claimed
US-20020081453-A1 Emitting layer and carrier transport layer using organic material between hole injection electrode and electron injection electrode, wherein chelate compound of chromone derivative with zinc is used as organic material in one layer SANYO ELECTRIC CO., LTD. (JP) 2002-06-27 US claimed
WO-2001003681-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS PRENDERGAST PATRICK T (IE) 2001-01-18 WO claimed
EP-1026924-A1 ORGANIC ELECTROLUMINESCENT DEVICE Sanyo Electric Co., Ltd. (JP) 2000-08-09 EP claimed
US-5703053-A TASTELESS INGESTIBLE COMPOUNDS WHICH REDUCE OR ELIMINATE UNDESIRABLE TASTES IN EATABLES BIORESEARCH, INC. (US) 1997-12-30 US claimed
US-5631038-A COMPOUNDS (TASTANDS) TO REDUCE OR ELIMINATE A BITTER OR METALLIC TASTE ARE ADDED TO FOODS CONTAINING SODIUM CHLORIDE BIORESEARCH, INC. (US) 1997-05-20 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230119060-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER CONTAINING, AS ACTIVE INGREDIENT, COMPLEX OF BIGUANIDE-BASED COMPOUND AND FLAVONE, HYDROXYFLAVONE, FLAVANONE, FLAVONE DERIVATIVE, HYDROXYFLAVONE DERIVATIVE, OR FLAVANONE DERIVATIVE SLC5A2, SLC5A1, SLC5A6 AR 904/4885CYP3A4 700/4885MAPT 3238/4885
US-20040265253-A1 Organic-inorganic hybrid material, composition for synthesizing the same, and manufacturing method of the same CAD, ILK, AOC1 AR 2897/4885CYP3A4 3684/4885MAPT 1402/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.