Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 6/20 | 0.51 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CDH1 | P12830 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1645103 | 0.90 | METAP2 (0.50) | LTA4HHAO1METAP2NOTUMMAPT | |
| Hydrochloric Acid SCHEMBL10565482 | 0.88 | METAP2 (0.48) | LTA4HHAO1METAP2NOTUMMAPT | |
| Methylamine SCHEMBL27885520 | 0.85 | METAP2 (0.46) | LTA4HHAO1METAP2NOTUMMAPT | |
| SCHEMBL3364770 | 0.83 | NPC1 (0.50) | LTA4HHAO1MAOA | |
| SCHEMBL1385301 | 0.81 | SCN4A (0.51) | MAPTL3MBTL1KDM4EMEN1ALDH1A1 | |
| SCHEMBL3367047 | 0.81 | LMNA (0.53) | LTA4HHAO1MAPTNPSR1KDM4E | |
| SCHEMBL4085552 | 0.81 | ESR2 (0.52) | LTA4HMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL6779765 | 0.80 | SCN9A (0.54) | HAO1MAPTL3MBTL1KDM4EMEN1 | |
| SCHEMBL16766999 | 0.79 | LMNA (0.36) | METAP2NOTUMMAPTMEN1KMT2A | |
| SCHEMBL3367634 | 0.78 | HAO1 (0.45) | LTA4HHAO1MAOAMAOBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104844609-A | Double-site irreversible Brutons tyrosine kinase inhibitor | HANGZHOU HERTZ PHARMACEUTICAL CO LTD | 2015-08-19 | — | — | CN | disclosed |