Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | DNM2 | P50570 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16378511 | 0.98 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1MAPTTDP1ACHE | |
| SCHEMBL21015410 | 0.90 | MAPT (0.56) | L3MBTL1ALDH1A1MAPTTDP1ACHE | |
| SCHEMBL2335362 | 0.90 | RAPGEF4 (0.50) | L3MBTL1ALDH1A1MAPTTDP1ACHE | |
| SCHEMBL5845349 | 0.83 | RAPGEF4 (0.52) | L3MBTL1ALDH1A1MAPTTDP1RAPGEF4 | |
| SCHEMBL12963494 | 0.81 | RAPGEF4 (0.50) | L3MBTL1ALDH1A1MAPTTDP1RAPGEF4 | |
| Carbamic Acid SCHEMBL5953514 | 0.79 | MAPT (0.50) | L3MBTL1ALDH1A1MAPTTDP1POLB | |
| SCHEMBL2756366 | 0.79 | RAPGEF4 (0.57) | ALDH1A1MAPTRAPGEF4 | |
| SCHEMBL3890402 | 0.78 | RAPGEF4 (0.43) | L3MBTL1ALDH1A1MAPTTDP1RAPGEF4 | |
| SCHEMBL4421023 | 0.78 | ESR1 (0.46) | ACHEABL1 | |
| SCHEMBL11292371 | 0.78 | ESR1 (0.46) | ACHEABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114933297-A | Preparation method of nanocrystalline/carbon nano tube composite super microsphere | 河南农业大学 | 2022-08-23 | — | — | CN | disclosed |