Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.38 |
| ▸ | TACR1 | P25103 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3498586 | 1.00 | TRPM8 (0.38) | TRPM8TACR1PSEN1PSEN2APH1B | |
| SCHEMBL2711844 | 1.00 | TRPM8 (0.38) | TRPM8TACR1PSEN1PSEN2APH1B | |
| SCHEMBL10059090 | 0.85 | TSHR (0.44) | TACR1MTNR1B | |
| SCHEMBL1037910 | 0.85 | TSHR (0.44) | TACR1MTNR1B | |
| SCHEMBL8196277 | 0.85 | TSHR (0.44) | TACR1MTNR1B | |
| SCHEMBL3580847 | 0.79 | TACR1 (0.44) | TACR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3498597 | 0.75 | NOD2 (0.38) | TACR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2713349 | 0.75 | NOD2 (0.38) | TACR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1709471 | 0.69 | KDM4E (0.40) | KDM4EALDH1A1POLBGAAMAPK1 | |
| SCHEMBL1709470 | 0.68 | KDM4E (0.40) | KDM4EALDH1A1POLBGAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805141-B1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (GB) | 2010-01-20 | — | — | EP | disclosed |