Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NLRP3 | Q96P20 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28157206 | 0.85 | TSHR (0.57) | RORCTSHRKMT2ANLRP3EIF2AK2 | |
| SCHEMBL29817649 | 0.85 | TSHR (0.57) | RORCTSHRKMT2ANLRP3EIF2AK2 | |
| SCHEMBL28156618 | 0.85 | RORC (0.73) | RORCKMT2AMAPTTP53MEN1 | |
| SCHEMBL29817762 | 0.85 | RORC (0.73) | RORCKMT2AMAPTTP53MEN1 | |
| SCHEMBL28156624 | 0.84 | RORC (0.62) | RORCTSHRKMT2ANLRP3MAPT | |
| SCHEMBL29817839 | 0.84 | RORC (0.62) | RORCTSHRKMT2ANLRP3MAPT | |
| SCHEMBL28823988 | 0.81 | RORC (0.65) | RORCKMT2ANLRP3MAPTTP53 | |
| SCHEMBL29817735 | 0.80 | RORC (0.57) | RORCTSHRKMT2ANLRP3EIF2AK2 | |
| SCHEMBL28823950 | 0.80 | RORC (0.57) | RORCTSHRKMT2ANLRP3EIF2AK2 | |
| SCHEMBL29817656 | 0.80 | RORC (0.57) | RORCTSHRKMT2ANLRP3EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107021923-B | Tetrahydroquinoline related bicyclic compound and application thereof | 中国科学院广州生物医药与健康研究院 | 2022-09-23 | — | — | CN | disclosed |
| CN-114790169-A | Tetrahydroquinoline related bicyclic compound and application thereof | 中国科学院广州生物医药与健康研究院 | 2022-07-26 | — | — | CN | disclosed |