Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | NLRP3 | Q96P20 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | TP53 | P04637 | 7/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | RORA | P35398 | 1/20 | 0.52 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.52 |
| ▸ | RORB | Q92753 | 1/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28157213 | 0.90 | RORC (0.80) | RORCNLRP3MAPTTP53POLB | |
| SCHEMBL29817579 | 0.90 | RORC (0.80) | RORCNLRP3MAPTTP53POLB | |
| SCHEMBL29817838 | 0.85 | RORC (0.63) | RORCNLRP3MAPTTP53EIF2AK2 | |
| SCHEMBL28156664 | 0.85 | RORC (0.63) | RORCNLRP3MAPTTP53EIF2AK2 | |
| SCHEMBL28823959 | 0.81 | RORC (0.63) | RORCKMT2ANLRP3MAPTTP53 | |
| SCHEMBL28843057 | 0.79 | RORC (0.55) | RORCKMT2ANLRP3MAPTTP53 | |
| SCHEMBL28157188 | 0.78 | RORC (0.79) | RORCNLRP3MAPTTP53LMNA | |
| SCHEMBL29817724 | 0.78 | RORC (0.79) | RORCNLRP3MAPTTP53LMNA | |
| SCHEMBL28843232 | 0.78 | RORC (0.55) | RORCKMT2ANLRP3MAPTTP53 | |
| SCHEMBL29817691 | 0.77 | RORC (0.80) | RORCMAPTTP53LMNANR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107021923-B | Tetrahydroquinoline related bicyclic compound and application thereof | 中国科学院广州生物医药与健康研究院 | 2022-09-23 | — | — | CN | disclosed |
| CN-114790169-A | Tetrahydroquinoline related bicyclic compound and application thereof | 中国科学院广州生物医药与健康研究院 | 2022-07-26 | — | — | CN | disclosed |