Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.50 |
| ▸ | NLRP3 | Q96P20 | 6/20 | 0.48 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28823931 | 0.91 | RORC (0.61) | RORCNLRP3EIF2AK2MAPTTP53 | |
| SCHEMBL28156627 | 0.85 | NLRP3 (0.52) | RORCNLRP3EIF2AK2MAPTTP53 | |
| SCHEMBL29817633 | 0.85 | NLRP3 (0.52) | RORCNLRP3EIF2AK2MAPTTP53 | |
| SCHEMBL28843232 | 0.85 | RORC (0.55) | RORCNLRP3EIF2AK2MAPTTP53 | |
| SCHEMBL28157192 | 0.78 | RORC (0.79) | RORCNLRP3EIF2AK2MAPTTP53 | |
| SCHEMBL29817571 | 0.78 | RORC (0.79) | RORCNLRP3EIF2AK2MAPTTP53 | |
| SCHEMBL28156620 | 0.78 | RORC (0.61) | RORCMAPTTP53LMNA | |
| SCHEMBL29817521 | 0.78 | RORC (0.61) | RORCMAPTTP53LMNA | |
| SCHEMBL29817614 | 0.77 | NLRP3 (0.57) | RORCNLRP3EIF2AK2MAPTTP53 | |
| SCHEMBL28157218 | 0.77 | NLRP3 (0.57) | RORCNLRP3EIF2AK2MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107021923-B | Tetrahydroquinoline related bicyclic compound and application thereof | 中国科学院广州生物医药与健康研究院 | 2022-09-23 | — | — | CN | disclosed |
| CN-114790169-A | Tetrahydroquinoline related bicyclic compound and application thereof | 中国科学院广州生物医药与健康研究院 | 2022-07-26 | — | — | CN | disclosed |