Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.55 |
| ▸ | NLRP3 | Q96P20 | 6/20 | 0.51 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | RORA | P35398 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
| ▸ | RORB | Q92753 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28823931 | 0.90 | RORC (0.61) | RORCNLRP3EIF2AK2LMNAKMT2A | |
| SCHEMBL29817753 | 0.86 | NLRP3 (0.57) | RORCNLRP3EIF2AK2LMNATP53 | |
| SCHEMBL28157184 | 0.86 | NLRP3 (0.57) | RORCNLRP3EIF2AK2LMNATP53 | |
| SCHEMBL28823964 | 0.85 | RORC (0.50) | RORCNLRP3EIF2AK2LMNAKMT2A | |
| SCHEMBL28823961 | 0.79 | RORC (0.45) | RORCNLRP3EIF2AK2LMNATP53 | |
| SCHEMBL28823988 | 0.78 | RORC (0.65) | RORCNLRP3EIF2AK2LMNAKMT2A | |
| SCHEMBL29817614 | 0.77 | NLRP3 (0.57) | RORCNLRP3EIF2AK2LMNATP53 | |
| SCHEMBL28157218 | 0.77 | NLRP3 (0.57) | RORCNLRP3EIF2AK2LMNATP53 | |
| SCHEMBL28823959 | 0.76 | RORC (0.63) | RORCNLRP3EIF2AK2LMNAKMT2A | |
| SCHEMBL29817690 | 0.74 | NLRP3 (0.56) | RORCNLRP3EIF2AK2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107021923-B | Tetrahydroquinoline related bicyclic compound and application thereof | 中国科学院广州生物医药与健康研究院 | 2022-09-23 | — | — | CN | disclosed |