Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 5/20 | 0.43 |
| ▸ | TYK2 | P29597 | 3/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29898289 | 1.00 | LMNA (0.43) | LMNASYKTYK2CSF1RHDAC3 | |
| SCHEMBL28824930 | 0.90 | SMN1; SMN2 (0.48) | LMNASYKTYK2CSF1RMAPT | |
| SCHEMBL28824948 | 0.88 | LMNA (0.48) | LMNASYKTYK2CSF1RHDAC3 | |
| SCHEMBL29898301 | 0.88 | LMNA (0.48) | LMNASYKTYK2CSF1RHDAC3 | |
| SCHEMBL28824923 | 0.88 | HDAC3 (0.48) | LMNASYKTYK2CSF1RHDAC3 | |
| SCHEMBL28824929 | 0.86 | CSF1R (0.45) | LMNASYKTYK2CSF1RHDAC3 | |
| SCHEMBL28824919 | 0.85 | BLK (0.49) | LMNASYKTYK2HDAC3HDAC1 | |
| SCHEMBL28824927 | 0.85 | AKR1C3 (0.46) | SYKCSF1RMAPTJAK2JAK1 | |
| SCHEMBL28824931 | 0.84 | MAPT (0.45) | LMNASYKCSF1RHDAC3HDAC1 | |
| SCHEMBL29898255 | 0.84 | MAPT (0.45) | LMNASYKCSF1RHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114989079-B | RIPK1 kinase target inhibitor and medical application thereof | 中国药科大学 | 2023-06-23 | — | — | CN | disclosed |
| CN-114989079-A | RIPK1 kinase target inhibitor and medical application thereof | 中国药科大学 | 2022-09-02 | — | — | CN | disclosed |