Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 10/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29898255 | 1.00 | MAPT (0.45) | MAPTNPC1RAB9ALMNAMEN1 | |
| SCHEMBL28824923 | 0.91 | HDAC3 (0.48) | MAPTNPC1RAB9ALMNASYK | |
| SCHEMBL29898301 | 0.87 | LMNA (0.48) | MAPTNPC1RAB9ALMNASYK | |
| SCHEMBL28824948 | 0.87 | LMNA (0.48) | MAPTNPC1RAB9ALMNASYK | |
| SCHEMBL28824952 | 0.85 | MAPT (0.46) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL29898313 | 0.85 | MAPT (0.46) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL28949528 | 0.85 | SYK (0.44) | MAPTNPC1RAB9ALMNASYK | |
| SCHEMBL28824953 | 0.85 | NPC1 (0.45) | MAPTNPC1RAB9ALMNAMEN1 | |
| SCHEMBL29898300 | 0.85 | SYK (0.44) | MAPTNPC1RAB9ALMNASYK | |
| SCHEMBL28824917 | 0.84 | LMNA (0.43) | MAPTNPC1RAB9ALMNASYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114989079-B | RIPK1 kinase target inhibitor and medical application thereof | 中国药科大学 | 2023-06-23 | — | — | CN | disclosed |
| CN-114989079-A | RIPK1 kinase target inhibitor and medical application thereof | 中国药科大学 | 2022-09-02 | — | — | CN | disclosed |