Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CSF1R | P07333 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29898313 | 1.00 | MAPT (0.46) | MAPTTP53CSF1RSMN1; SMN2GAA | |
| SCHEMBL28824923 | 0.89 | HDAC3 (0.48) | MAPTCSF1RSMN1; SMN2NPC1RAB9A | |
| SCHEMBL29898302 | 0.89 | KDR (0.49) | MAPTTP53SMN1; SMN2GAANPC1 | |
| SCHEMBL28824932 | 0.89 | KDR (0.49) | MAPTTP53SMN1; SMN2GAANPC1 | |
| SCHEMBL28824937 | 0.88 | AKR1C3 (0.46) | MAPTTP53CSF1RSMN1; SMN2NPC1 | |
| SCHEMBL29898299 | 0.88 | AKR1C3 (0.46) | MAPTTP53CSF1RGAASYK | |
| SCHEMBL28824927 | 0.88 | AKR1C3 (0.46) | MAPTTP53CSF1RGAASYK | |
| SCHEMBL28824948 | 0.87 | LMNA (0.48) | MAPTCSF1RSMN1; SMN2NPC1RAB9A | |
| SCHEMBL29898301 | 0.87 | LMNA (0.48) | MAPTCSF1RSMN1; SMN2NPC1RAB9A | |
| SCHEMBL28949528 | 0.85 | SYK (0.44) | MAPTCSF1RSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114989079-B | RIPK1 kinase target inhibitor and medical application thereof | 中国药科大学 | 2023-06-23 | — | — | CN | disclosed |
| CN-114989079-A | RIPK1 kinase target inhibitor and medical application thereof | 中国药科大学 | 2022-09-02 | — | — | CN | disclosed |